Abstract
The influence of the new inotropic and vasodllating agent UDCG-115 on hemodynamics and myocardial oxygen metabolism was investigated in 11 patients with idiopathic dilated cardiomyopathy (New York Heart Association class II to III). After intravenous administration of UDCG-115, cardiac index increased from 3.03 ± 0.68 to 3.76 ± 1.07 L/min/m 2 ( p < 0.01), left ventricular ejection fraction increased from 31 ± 13 to 39 ± 16% ( p < 0.01), and maximum rate of left ventricular pressure rise increased from 935 ± 248 to 1056 ± 284 mm Hg/sec ( p < 0.05). Left ventricular end-diastolic wall stress (index of preload) and left ventricular end-systolic wall stress (index of afterload) decreased by 41% ( p < 0.01) and 34% ( p < 0.001), respectively. Heart rate did not change significantly. With UDCG-115 myocardial oxygen consumption decreased from 14.3 ± 5.1 to 10.6 ± 3.8 ml/min/100 gm ( p < 0.05), and the ratio of myocardial oxygen supply to myocardial oxygen demand increased from 1.40 ± 0.08 to 1.53 ± 0.17 ( p < 0.05). Thus intravenous UDCG-115 improves left ventricular function by increasing inotropism and reducing preload and afterload in patients with idiopathic dilated cardiomyopathy and moderate congestive heart failure. The systemic hemodynamic actions are associated with favorable effects on myocardial energetics.
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