Abstract
Objective:X-ray cross-complementing group 1 (XRCC1) and 8 Oxo guanine DNA-glycosylase 1 (OGG1) genes are implicated in the repair of single-stranded breaks (SSBRs) and base excision repair (BER) pathways. Common polymorphisms in DNA repair genes are supposed to decrease the capability of DNA repair and cause genetic instability. This study was designed to investigate the association between XRCC1 (rs25487) and OGG1 (rs1052133) polymorphisms and susceptibility to colorectal cancer (CRC) in the Ahvaz city, south-west Iran. Methods:This case- control study comprised 150 patients and 150 controls that were selected from 2 educational hospitals in Ahvaz. They were matched for age and gender, and their genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results:Our results indicate that the frequency of the Gln (A) allele of XRCC1 (rs25487) is significantly higher in colorectal cancer patients, compare to controls (p = 0.01, OR: 1.54, 95% CI 1.9–13.3). Significant increased risk of cancer was observed in XRCC1 (rs25487) genotypes (p = 0.001 OR: 5.3, 95% CI 1.9–14.2 for Gln / Gln), while no association was found between OGG1 (rs1052133) and colorectal cancer risk (p = 0.6). Conclusion:Our study suggests that XRCC1 (rs25487) polymorphism might be associated with an increasing risk of CRC in Ahvaz. It also demonstrates positive correlation between the XRCC1 (rs25487) genotypes and demographic characteristics, such as smoking and increased age in patients and control groups.
Highlights
Colorectal cancer (CRC) is one of the most common malignancies and the fourth leading cause of death by cancer in the world (Arnold et al, 2017)
Our results indicate that the frequency of the Gln (A) allele of X-ray cross-complementing group 1 (XRCC1) is significantly higher in colorectal cancer patients, compare to controls (p = 0.01, odds ratios (OR): 1.54, 95% confidence intervals (CI) 1.9–13.3)
Significant increased risk of cancer was observed in XRCC1 genotypes (p = 0.001 OR: 5.3, 95% CI 1.9–14.2 for Gln / Gln), while no association was found between Oxo guanine DNA-glycosylase 1 (OGG1) and colorectal cancer risk (p = 0.6)
Summary
Colorectal cancer (CRC) is one of the most common malignancies and the fourth leading cause of death by cancer in the world (Arnold et al, 2017). The DNA repair gene XRCC1 is implicated in the repair of single-stranded breaks (SSBRs) and base excision repair (BER) that has been mapped to the human chromosome region 19q13 (Mohrenweiser et al, 1989; Huang et al, 2015). Another DNA repair gene that has an essential role in base excision repair is OGG1 that is located in the chromosome region 3p26. XRCC1 has unknown enzymatic activity and is considered to operate as a scaffold protein for base
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