Influence of Tumor Volume on the Fluence Rate Within Human Breast Model Using Continuous-Wave Diffuse Optical Imaging: A Simulation Study.

Abstract

Objective: This article investigates the effect of varying breast tumor size on the fluence rate distribution within a breast model during the diffuse optical imaging procedure. Background: Early detection of breast cancer is of significant importance owing to its wide spread among women worldwide. Mastectomy surgery became very common due to the late detection of breast cancers by the conventional diagnostic methods such as X-ray mammography and magnetic resonance imaging. On the contrary, optical imaging techniques provide a safe and more sensitive methodology, which is suitable for the early detection criteria. Methods: The implementation was performed based on simulating multiple detectors placed on the outer surface of a human breast model to compute the optical fluence rate after probing the breast (normal and different tumor sizes) with laser irradiation. Different laser wavelengths ranging from the red to near-infrared rays spectral range were examined to determine the optimum fluence rate that shows the highest capability to differentiate between normal and cancerous breasts. A three-dimensional breast model was created using the COMSOL multiphysics package where the optical fluence rate was estimated based on the finite-element solution of the diffusion equation. Results: To evaluate the efficiency of the suggested technique for identifying cancers and discriminate them from normal breast at various wavelengths (600-1000 nm) and several tumor sizes. Conclusions: The obtained results reveal different fluence rate distributions in the breast with different radius tumors, especially at 600 nm due to the significant differences in the scattering coefficient between malignancies and healthy tissue.