Abstract
Trimetazidine, 1-(2, 3, 4-trimethoxybenzyl) piperazine, was examined in relation to its influence on the inotropic action of strophanthin-G in electrically driven isolated guinea-pig atria. Trimetazidine slightly diminished the effect of strophanthin-G in high Ca, high K, and low K media as well as in Locke's solution. The early stage reduction of the effect of strophanthin-G caused by a low Ca medium was prevented by the presence of trimetazidine. In a low Na medium, the effect of strophanthin-G was manifested by trimetazidine. From these results, it may be assumed that trimetazidine augments the posi-tive inotropic action of strophanthin-G through its prevention of the loss of available calcium ions in atria kept in a low Ca or low Na medium.
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