Influence of triiodothyronine, amphetamine, and dinitrophenol (DNP) on the reduced metabolic rate in uremic and acidotic rats

Abstract

In acute HCl-induced acidosis and in acute uremia due to bilateral nephrectomy oxygen consumption is reduced by about 50%. This is normalized by amphetamine treatment in the uremic state or prevented by triiodothyronine pretreatment in acidosis. The lipolytic effects of both, triiodothyronine and amphetamine, are present under acidosis as well as under uremia. The investigations suggest that different mechanisms are responsible for the reduction of the metabolic rate in acidosis and uremia; on principle, normalization of the metabolic defect is possible.