Abstract
In order to elucidate the relationship between the stimulation of the sensory nerves of the rhino- pharyngeal region and irritation syndrome. the electrical influence of the irritation of the trigem- inus and glosso-pharyngeus upon the vago-vagal reflex was studied in rabbits. The vago-vagal reflex was recorded as the elctrical response obtai- ned from a cervical vagus nerve when the vagus nerve in the opposite side was electrically stimula- ted. 1) Repetitive stimulation of the trigeminus nerve augmented the vago-vagal reflex response. 2) Single electrical stimulation of the trige- minus nerve elicited response in the ipsi-lateral vagus nerve as well as contra-lateral vagus nerve. 3) These electrical responses are markedly exaggerated by administration of strychnine, and depressed by administration of promethazine hy- 4) Administration of mephenesin immediately abolished these reflex responses. 5) Stimulation of the glosso-pharyngeal nerve failed to elicit response in the vagns nerve, even after pretreatreatment with strychnine. These findings were interpreted as indicating the existence of a pathway through the sensory fibers of the trigeminus nerve to the vagus nerves, through which irritative stimuli from the rhino- pharyngeal area can be transmitted to exert dele- terious effects in the vital organs.
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