Abstract
The effect of trace concentrations of surfactants (Tween 80, egg lecithin and sodium lauryl sulphate) on the bioavailability of nifedipine was investigated in rats in normal physiological condition and with the neomycin induced malabsorption syndrome. Tween 80 and lecithin, added under their critical miscellar concentration levels, were found to enhance nifedipine bioavailability in the case of physiological equilibrium and in the induced malabsorption syndrome. An increase of bioavailability promoted by addition of lauryl sulphate of sodium was not statistically significant.
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