Abstract
Titanium dioxide can adhere with human epithelial cells and have good tolerability. Present work has been undertaken to explore the influence of TiO2 on mucosal permeation of aceclofenac. Mucosal permeation of aeclofenac solution containing TiO2 has been carried out. In fourier transform infrared spectrosopy (FTIR), the intensity of the peaks has decreased along with the increase of TiO2 content in the formulation indicating a possible binding between drug and TiO2. Melting enthalpy has been decreased with the increased content of TiO2 in the solid. The status of crystal strain and dislocation density of TiO2 and aceclofenac in the solid state formulation has also been evaluated from Xray Diffraction data using Debye-Scherrer's equation. Mucosal permeation of aceclofenac has shown sustained effect for more than 20 h in presence of titanium dioxide. Titanium dioxide could be used in designing formulation for sustaining mucosal aceclofenac delivery after performing risk assessment study.
Highlights
Titanium Dioxide (TiO2) is a biocompatible and stable material,[1] and has a wide range of application in various kinds of cosmetics
2018 reported that TiO2 has a property to attach with human epithelial cells along with a good tolerability.[5]
In this present study the influence of TiO2 has been explored on the mucosal permeation of aceclofenac in liquid formulation after topical administration
Summary
Titanium Dioxide (TiO2) is a biocompatible and stable material,[1] and has a wide range of application in various kinds of cosmetics. In vitro prolonged release has been studied for transmucosal delivery of aceclofenac using mucoadhesive dillenia fruit gum.[15] Katara et al, prepared a nano particle formulation of aceclofenac and claimed that the drug efficacy in local action can be improved if residence time of the formulation is amplified.[16]. In this present study the influence of TiO2 has been explored on the mucosal permeation of aceclofenac in liquid formulation after topical administration.
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