Influence of ticlopidine alone and in combination with aspirin on biochemical parameters in rats

Abstract

Event Abstract Back to Event Influence of ticlopidine alone and in combination with aspirin on biochemical parameters in rats Z Stanojevic1*, R Mitic1, S Stevic1, V Nestorivic2, M Miletic2 and Z Bukumiric3 1 University of Pristina, Institute of Pharmacology and Toxicology, Kosovo 2 University of Pristina, Institute of Physiology, Kosovo 3 University of Pristina, Institute of Medical Statistics and Informatics, Kosovo A combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting. Ticlopidine is often associated with abnormal liver function test values. The purpose of this study was to evaluate the influence of ticlopidine, administered alone and in combination with aspirin, on biochemical parameters. The experiment was conducted on white laboratory rats, type Wistar. Twenty four rats were divided in three groups and they received one of the following treatments for three days: group I - control; group II - ticlopidine (125 mg/kg/day i.p.) and group III - ticlopidine+aspirin combination (125 mg/kg/day+50 mg/kg/day i.p.). After the treatment the animals were anaesthetised with ether and blood for further analyses was taken by cardiopunction. Total cholesterol serum level was significantly increased in group treated with ticlopidine compared to control (p<0.01). In group treated with ticlopidine+aspirin combination total cholesterol serum level was increased, but not significantly. Also, the total bilirubin concentration and serum activity of alkaline phosphatase were significantly elevated only in ticlopidine treated group compared to control (p<0.001). Serum AST and ALT activities were not significantly elevated in all treating groups. Based on obtained results it can be observed that the values of liver function parameters are higher in group treated with ticlopidine than in group treated with ticlopidine+aspirin combination. Keywords: Ticlopidine, Aspirin, coronary artery stenting Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Poster Topic: Xenobiotic toxicity Citation: Stanojevic Z, Mitic R, Stevic S, Nestorivic V, Miletic M and Bukumiric Z (2010). Influence of ticlopidine alone and in combination with aspirin on biochemical parameters in rats. Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00200 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Oct 2010; Published Online: 04 Nov 2010. * Correspondence: Dr. Z Stanojevic, University of Pristina, Institute of Pharmacology and Toxicology, Kosovska Mitrovica, Kosovo, zorica_stanojevic@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Z Stanojevic R Mitic S Stevic V Nestorivic M Miletic Z Bukumiric Google Z Stanojevic R Mitic S Stevic V Nestorivic M Miletic Z Bukumiric Google Scholar Z Stanojevic R Mitic S Stevic V Nestorivic M Miletic Z Bukumiric PubMed Z Stanojevic R Mitic S Stevic V Nestorivic M Miletic Z Bukumiric Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.