Abstract
It is customary to regard the thyroid hormone as a stimulator of catabolism, in particular of protein catabolism. However, the impaired growth of human cretins, of thyroidectomized rats (Evans, Simpson, and Pencharz 1939) and goats (Reineke, and Turner 1941) as well as the resumption of growth resulting from thyroid medication indicate that the influence of thyroid hormone on metabolic processes is more complex. Growth is, of necessity, associated with a prevalence of anabolic processes, especially of proteins. The experiments reported in this paper were undertaken in order to determine, (a) whether thyroxine induces nitrogen retention (protein anabolism), and (b) if so, under what conditions anabolic or catabolic effects would predominate. mateeial and methods The rats used in most of the experiments were descendants of the Wistar Strain, bred by a local dealer; rats of the Sprague-Dawley strain were employed in some instances. Their weights varied between 200 and 250 grams. Thyroidectomy was performed b...
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