Abstract
ALTHOUGH an inverse relation between the level of thyroid activity and the content of one or other lipid constituent in the blood of both man and animals has been repeatedly observed (1–5), nothing is known of the mechanism that governs this relation. In an attempt to determine its nature, it seemed desirable t o examine first the permanency and degree of consistency of lipid changes that follow complete excision of the gland. In the present investigation, the choleseterol, phospo lipids and total fatty acids of the blood were observed at short intervals for as long as 214 days after thyroidectomy. It is shown that the blood lipid response to thyroidec tomy is quite irregular and variable. Despite the presence of greatly increased amounts of lipids in the blood of the thyroidectomizied dog, sudden reductions in their amounts or even a return to normal concentrations may occur.
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