Abstract
Energy balance and brown adipose tissue (BAT) metabolism were studied in rats maintained on stock or 'cafeteria' diet, and injected with either saline or triiodothyronine (T3, 10 micrograms/100 g b.wt./d) for 14 d. Cafeteria-fed rats showed large increases in metabolizable energy intake, energy expenditure and BAT mass, Na+, K+-ATpase activity and mitochondrial GDP binding. In stock fed rats, T3 also stimulated energy intake, metabolic rate and BAT mass and Na+, K+-ATPase activity, but did not affect GDP binding. Hyperthyroidism potentiated the effects of cafeteria feeding on energy expenditure and BAT mass, but BAT Na+, K+-ATPase activity was only slightly higher than that of the euthyroid cafeteria rats, and GDP binding was similar for both groups. These results confirm the involvement of BAT in diet-induced thermogenesis and show that this is potentiated by hyperthyroidism. The data also suggest that thyroid thermogenesis may result, at least partly, from stimulation of BAT.
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Schedule a callMore From: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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