Abstract
Daily doses of propylthiouracil (PTU) as low as 50 μg per rat result in a depression of the peripheral deiodination of Lthyroxine in thyroidectomized animals isotopically equilibrated with I131-labeled L-thyroxine. Administration of PTU is accompanied by similar alterations of the peripheral metabolism of triiodo-L-thyronine in thyroidectomized rats maintained with the latter hormone. Maximal extrathyroidal effects of PTU on the metabolism and effectiveness of L-thyroxine are obtained with doses of 500 ng per rat or higher. The influence of a given dose of PTU was studied in groups of thyroidectomized rats which were equilibrated isotopically with varying doses of L-thyroxine ranging from 0.5 to 50 μg per rat per day, and it was observed that the drug depressed thyroxine deiodination to a rather constant proportion of the available hormone. Therefore the effects of PTU on the actual amount deiodinated peripherally may be overcome by adequately increasing the hormonal supply. Thiourea, potassium thiocyanat...
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