Abstract
Fluidized bed layering granulation is frequently used to formulate particles of high quality. From previous studies, it is well known that the dynamic behavior of the process, as well as the product properties depend on operating parameters. The process is characterized by heat and mass transfer between fluidized particles and the surrounding fluidization medium. To investigate the mutual influence between particle phase and fluidization medium, a dynamic model is introduced. The model comprises two parts: a population balance model to describe the evolution of the particle sizes and a system of ordinary differential equations to account for thermal conditions. For the first time, the dynamic model considers the bidirectional coupling of particles and fluidization medium in fluidized bed layering granulation. By means of simulations, it is shown that the derived model is capable of reproducing the experimental findings.
Highlights
Fluidized bed layering granulation (FBLG) is a widely-applied particle formulation process.For instance, pharmaceutical, food, and fertilizer industries utilize FBLG to produce granules of high quality (Mörl et al [1])
The presented population balance models (PBMs) is based on the dynamic model of FBLG presented by Radichkov et al [16]
The resulting system of ordinary differential equations was solved with the MATLAB built-in solver ode15s
Summary
Fluidized bed layering granulation (FBLG) is a widely-applied particle formulation process. The influence of selected process conditions on product porosity as a key property was investigated by Rieck et al [9] and Hoffmann et al [10] for the formation of sodium benzoate granules. Based on the PBM presented by Heinrich et al [15], Radichkov et al [16] investigated the influence of operation parameters on the qualitative behavior of the process by means of a rigorous stability analysis. The interplay of thermal conditions and product properties, as well as the dynamic behavior of the FBLG depicted in Figure 2 is studied.
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