Influence of the Severity of Metabolic Acidosis on the Response to Bicarbonate Administration.

Abstract

Meeting Abstracts1 May 1973Influence of the Severity of Metabolic Acidosis on the Response to Bicarbonate Administration.Serafino Garella, M.D., F.A.C.P., Clare L. Dana, M.D., Joseph A. Chazan, M.D., F.A.C.P.Serafino Garella, M.D., F.A.C.P.Search for more papers by this author, Clare L. Dana, M.D.Search for more papers by this author, Joseph A. Chazan, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-828_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the treatment of metabolic acidosis the amount of NaHCO3 needed to produce the desired increment in plasma bicarbonate concentration (HCO3-) is usually calculated assuming an apparent space of distribution of HCO3- approximating 50% of body weight. In most patients the changes in plasma HCO3-are reasonably well correlated with the dose of administered HCO3-, except when there is ongoing excessive acid production, as in patients with lactic acid acidosis. In this case continuing HCO3- titration results in large increases in the apparent space of distribution of HCO3- ("alkali resistance").Recently we have observed several patients with profound metabolic acidosis (plasma... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode Island. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 828-828KeywordsAcidosisAttentionBicarbonatesBlood plasmaBody weightLactic acidLactic acidosis Issue Published: 1 May 1973 PDF downloadLoading ...