Abstract
BackgroundFairly recent data highlight the role of programmed cell death and autoimmunity, as potentially important factors in the pathogenesis of chronic obstructive airway diseases. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity.MethodThe study was performed on the peripheral blood of patients with atopic bronchial asthma with different severity. The Immunological aspects were determined with ELISA, the fluorimetric method and the method of precipitation with polyethylene glycol. And the quantification of the parameters of the programmed cell death was performed by the method of flow cytometry and electron microscopy method.ResultsThe data obtained from morphological and biochemical parameters show the deregulation of Programmed Death of lymphocytes of patients with atopic bronchial asthma but individual for each group of patients. This dysfunction might induce the secretion of autoantibodies against DNA. This could explain the accumulation of circulating immune complex with average size considered as the most pathogenic in patients with bronchial asthma especially in the patients of serious severity. It should be noted that Patients with bronchial asthma of mild and severe severity had different way and did not have the same degree of deficiency of the immune system.ConclusionThese data suggested that apoptotic factor of lymphocytes may play an important role in controlling immunity of patients with atopic bronchial asthma.
Highlights
Each pathological process resembles a stereotypical reaction of the organism due to the action of various pathogens
It should be noted that Patients with bronchial asthma of mild and severe severity had different way and did not have the same degree of deficiency of the immune system. These data suggested that apoptotic factor of lymphocytes may play an important role in controlling immunity of patients with atopic bronchial asthma
The role of apoptosis in the development of the pathological process is less obvious. It seems that this form of cell death is not an indispensable component of the typical pathological process, but rather the malfunction of apoptosis is the cause of a certain number of diseases [6,16,17]
Summary
Each pathological process resembles a stereotypical reaction of the organism due to the action of various pathogens. Programmed cell death (PCD), which is similar embryogenesis and in the post-embryonic metamorphosis [11]. The deregulation of this process plays an important role in many diseases such as: neurodegenerative diseases (Alzheimer’s and Parkinson’s) [7,10,12], myodystrophy and cardiomyopathy diseases [13,14], the aging and infections [12] and malignant tumors [7]. The role of apoptosis in the development of the pathological process is less obvious It seems that this form of cell death (as opposed to necrosis) is not an indispensable component of the typical pathological process, but rather the malfunction of apoptosis is the cause of a certain number of diseases [6,16,17]. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity
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