Influence of the presence of HCV-RNA in peripheral blood mononuclear cells on the clinical course of chronic hepatitis C in children

Abstract

The clinical course of chronic hepatitis C (CHC) is generally asymptomatic in children. The aim of this study was to examine the influence of HCV RNA in peripheral blood mononuclear cells (PBMCs) on the clinical course of CHC considering age at the time of infection, length of infection, hepatitis virus C (HCV) genotype, baseline viral load, ALT activity, the degree of liver fibrosis and oncologic history. The study group included forty children, aged 6-18 years with diagnosed CHC. Children were divided into two subgroups: group A (n = 28), with HCV-RNA found in PBMCs and group B (n = 12), with negative results of HCV-RNA in PBMCs. Chosen parameters were analyzed in both study groups according to the aim of the study. Similar age at the time of infection and the length of infection was found in both groups. The majority of the children were infected with genotype 1. Viral load, the stage of fibrosis and ALT activity were comparable in both groups. History of pediatric malignancy concerned the vast majority of children. Presence of HCV-RNA does not seem to influence the clinical course of HCV infection in children.