Abstract
A series of experiments was undertaken to determine the acute effects of hypophysectomy and the administration of human chorionic gonadotropin (HCG), ovine luteinizing hormone (LH) and ovine prolactin on progesterone secretion rate in mature reproductively active ewes. Hypophysectomy at midcycle resulted in a highly significant 12-fold decrease below that of either sham-operated or intact animals in the secretion rate of progesterone within 5 hr. This decrease was composed of a 3-fold drop in ovarian venous progesterone concentration and a 4-folddecrease in the rate of ovarian blood flow. Treatment of hypophysectomized animals with 3000 IU HCG, 50 mg LH or 50 mg prolactin resulted in significant increases in ovarian venous progesterone concentration and progesterone secretion rate within 10 to 20 min. It was concluded that the functional activity of the sheep corpus luteum (CL) is regulated by the anterior pituitary, and that both LH and prolactin are capable of stimulating progesterone output. (Endocrino...
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