Abstract
The chromatographic behavior of para -substituted amides of α -phenylacetic, benzoic, propanoic, and 2,2-dimethylpropanoic acid has been studied in reversed-phase thin-layer chromatography on silica gel impregnated with paraffin oil. Mobile phases used were acetone-water, methanol-water, and dioxane-water. R M 0 values were calculated by linear extrapolation of retention to 0% organic modifier for each mobile phase. The relationships between R M 0 values obtained with different organic modifiers in the mobile phases are discussed. C 0 values were obtained from the slopes and intercepts of linear relationships between retention and volume fraction of modifier. Correlation between partition coefficient, log P , and R M 0 and between log P and C 0 was examined. Results show that C 0 is a better measure of the lipophilicity of the amides than R M 0 .
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