Influence of the medication administration sequence of taxanes and anthracyclines on the recent effect in patients with breast cancer

Abstract

Objective To observe the influence of the medication administration sequence of taxanes and anthracyclines on the recent effect in patients with breast cancer, in order to improve the prognosis of patients with breast cancer. Methods From June 2010 to June 2013, 60 patients with breast cancer were selected as the research object according to the medication administration sequence, they were divided into observation group and control group, with 30 cases in each group. The observation group was treated with docetaxel on the first day and epirubicin on the second day; the control group was treated with epirubicin on the first day, and docetaxel on the second day. The clinical efficacy, adverse reactions and short-term survival rates were compared between the two groups. Results The total effective rate and clinical benefit rate of the observation group were 76.67% and 93.33%, there were no significant difference between the two groups (P>0.05). The 1, 2 year survival rate in observation group was 93.33% and 86.67%, there were no significant difference between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions In the neoadjuvant treatment of breast cancer, there were not significantly difference between taxanes and anthracyclines drugs in sequence on the patient’s clinical curative effect and short-term survival. Key words: Breast cancer; Taxanes; Anthracyclines; Medication administration sequence; Recent effect