Abstract
ABSTRACT Rats were treated intraperitoneally (ip) with saline, lithium chloride or propylthiouracil (PTU) for two weeks. The uptake of iodine-125 and iodine-131 into the thyroid gland was markedly reduced by PTU and lithium treatment. PB125I was significantly reduced after lithium and PTU, as was the PBI. There was no evidence for an inhibitory effect of lithium on the biosynthesis of thyroxine or thyroglobulin. Thyroxine synthesis was markedly affected by PTU-treatment. The iodination of tyrosine was particularly reduced.
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