Abstract
Although studies have shown that an IUD inhibits implantation in the hamster (Orsini, 1965; Richardson & Ansbacher, 1971) and rat (Doyle & Margolis, 1964) the mechanism involved is not clear. Saksena, Lau & Castracane (1974) suggested that inhibition of implantation in the hamster was due to a decrease in progesterone secretion from the ovary adjacent to the IUD which was brought about by an increase in prostaglandin secretion from the IUD-containing horn. Prasad, Joshi & Labhsetwar (1973) reported a reduction in progesterone secretion from the ovary adjacent to the IUD in the rat and concluded that this change partly accounted for the local antifertility effects of the device. It is not clear from these studies, however, whether the ovaries adjacent to the IUD can maintain pregnancy in the other horn and we therefore examined the effects of a unilateral IUD on the maintenance of pregnancy in rats and hamsters.
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