Abstract
lipoprotein receptor and inhibited the accumulation and activity of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. Phosphorylation of AMP-activated protein kinase was stimulated by Palmiwon. In menopausal hyperlipidemic rats, Palmiw on reduced retroperitoneal and peri-renal fat accumulation, serum lipids, the atherogenic index, cardiac risk factors, intima-media thickness, and nonalcoholic steatohepatitis scores relative to menopausal hyperlipidemic control rats. Conclusion:These results indicated that Palmiwon inhibits lipid accumulation without estrogenic activity in the breast. Therefore, Palmiwon may have potential as both a preventive and therapeutic agent for the treatment of hyperlipidemia in menopausal females. Contact: Byoung Seob Ko, bsko@kiom.re.kr
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