Abstract
In this cross-sectional study, we investigated whether a foveal curvature affects the development of two major myopic macular complications, myopic traction maculopathy (MTM) and myopic choroidal neovascularization (mCNV). In high myopic eyes (axial length ≥ 26.5 mm, refractive error ≤ −6 diopters) with posterior staphyloma, three different parameters of foveal curvature (staphyloma height, coefficient a, and curvature index) calculated based on the retinal pigment epithelium hyperreflective line in spectral domain optical coherence tomography image were compared among the MTM (72 eyes), mCNV (58 eyes), and control (69 eyes) group. The three curvature parameters showed a significant correlation with each other (all P’s < 0.001). The axial length, refractive error, and staphyloma types were comparable among the groups, but the means of all three curvature parameters were significantly greater in the MTM group compared to the mCNV and control groups (all P’s < 0.001). Furthermore, the curvature parameters had a significant correlation with myopic severity in the MTM group, but not in the other groups. These results suggest that a steeper change of foveal curvature plays a role in the development of MTM but not mCNV in high myopes.
Highlights
In this cross-sectional study, we investigated whether a foveal curvature affects the development of two major myopic macular complications, myopic traction maculopathy (MTM) and myopic choroidal neovascularization
We investigated whether the presence of the two major myopic complications involving macula, the MTM and myopic choroidal neovascularization (mCNV), has association with the foveal curvature in the spectral domain optical coherence tomography (OCT) images in high myopic eyes with posterior staphyloma
The mean age was significantly lower and the mean best-corrected visual acuity (BCVA) was significantly better than the MTM or mCNV group
Summary
In this cross-sectional study, we investigated whether a foveal curvature affects the development of two major myopic macular complications, myopic traction maculopathy (MTM) and myopic choroidal neovascularization (mCNV). In high myopic eyes (axial length ≥ 26.5 mm, refractive error ≤ −6 diopters) with posterior staphyloma, three different parameters of foveal curvature (staphyloma height, coefficient a, and curvature index) calculated based on the retinal pigment epithelium hyperreflective line in spectral domain optical coherence tomography image were compared among the MTM (72 eyes), mCNV (58 eyes), and control (69 eyes) group. The curvature parameters had a significant correlation with myopic severity in the MTM group, but not in the other groups These results suggest that a steeper change of foveal curvature plays a role in the development of MTM but not mCNV in high myopes. We investigated whether the presence of the two major myopic complications involving macula, the MTM and mCNV, has association with the foveal curvature in the spectral domain OCT images in high myopic eyes with posterior staphyloma. We evaluated the clinical significance of the curvature index as a new method to determine foveal curvature
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