Influence of the amount of intermetallics on the degradation of Mg-Nd alloys under physiological conditions

Yaping Zhang,Yuanding Huang,Frank Feyerabend,Carsten Blawert,Weimin Gan,Emad Maawad,Sihang You,Sarkis Gavras,Nico Scharnagl,Julia Bode,Carla Vogt,Daniela Zander,Regine Willumeit-Römer,Karl Ulrich Kainer,Norbert Hort

doi:10.1016/j.actbio.2020.11.050

Abstract

The influence of amount of intermetallics on the degradation of as-extruded Mg-Nd alloys with different contents of Nd was investigated via immersion testing in DMEM+10% FBS under cell culture conditions and subsequent microstructural characterizations. It is found that the presence of intermetallic particles Mg41Nd5 affects the corrosion of Mg-Nd alloys in two conflicting ways. One is their negative role that their existence enhances the micro-galvanic corrosion. Another is their positive role. Their existence favours the formation of a continuous and compact corrosion layer. At the early stage of immersion, their negative role predominated. The degradation rate of Mg-Nd alloys monotonously increases with increasing the amount of intermetallics. Mg-5Nd alloy with maximum amount of intermetallics suffered from the most severe corrosion. With the immersion proceeding (≥7 days), then the positive role of these intermetallic particles Mg41Nd5 could not be neglected. Owing to the interaction between their positive and negative roles, at the later stage of immersion the corrosion rate of Mg-Nd alloys first increases with increasing the content of Nd, then reaches to the maximum at 2 wt. % Nd. With a further increase of Nd content, a decrease in corrosion rate occurs. The main corrosion products on the surfaces of Mg-Nd alloys include carbonates, calcium-phosphate, neodymium oxide and/or neodymium hydroxide. They are amorphous at the early stage of immersion. With the immersion proceeding, they are transformed to crystalline. The existence of undegradable Mg41Nd5 particles in the corrosion layer can enhance the crystallization of such amorphous corrosion products.

Highlights

Numerous recent studies have emphasized that magnesium and its alloys could work as temporary implants due to their good biocompatibility, density (1.74-2.0 g/cm3), compressive yield stress (65-100 MPa) and elastic modulus (41- 45 GPa), which are fairly close to that of natural bones [1,2,3]
The improvement of strength of magnesium alloys can be achieved through grain refinement, solid solution and precipitation strengthening [4,5,6]
Our preliminary results indicate that when iron containing magnesium alloys was immersed in DMEM + 10% FBS, its harmful effect on the corrosion resistance was not so apparent as that observed in NaCl solution [44]

Summary

Introduction

Numerous recent studies have emphasized that magnesium and its alloys could work as temporary implants due to their good biocompatibility, density (1.74-2.0 g/cm3), compressive yield stress (65-100 MPa) and elastic modulus (41- 45 GPa), which are fairly close to that of natural bones [1,2,3]. The main obstacle for their applications is to balance the strength and degradation rate. The improvement of strength of magnesium alloys can be achieved through grain refinement, solid solution and precipitation strengthening [4,5,6]. Precipitation strengthening is one of the most popular approach [7]. Many of the already developed biodegradable magnesium alloys contain intermetallics [8,9,10,11]. The intermetallic phases can act as either a continuous network barrier to retard corrosion propagation [12], or as a galvanic cathode to accelerate corrosion of the Mg matrix [9], or as a micro-anode to dissolve preferentially at the initial corrosion stage [10]

Results

Discussion

Conclusion