Abstract
Morinobu Shigeru, Norihiko Kuwayama Tomiko Kawanami, Naoyuki Okuyama, Michihiro Takahashi, Shiro Totsuka and Masao Endoh: Influence of the Acute Stress on Agonist-Stimulated Phosphoinositide Hydrolysis in the Rat Cerebral Cortex. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1992, 16(4):561–570. 1. 1. The present study was carried out in order to elucidate the influence of the acute stress on α 1-adrenergic, serotonin-2 (5-HT 2) and muscarinic cholinergic (M-Ach) receptors-mediated phosphoinositide (PI) hydrolysis in rat cerebral cortex slices. 2. 2. In rat cerebral cortex slices, noradrenaline (NA), serotonin (5-HT) and carbachol stimulated [ 3H]inositol-monophosphate (IP 1) accumulation in a concentration-dependent manner. 3. 3. The forced swimming test (FST) for 15 min induced a significant reduction of 5-HT-stimulated [ 3H] IP 1 accumulation, but this stress situation did not produce a significant alteration of NA- and carbachol-stimulated [ 3H] IP 1 accumulation. 4. 4. The FST for 15 min did not affect the density and affinity of α1-adrenergic, 5-HT 2 and M-Ach receptors. 5. 5. In a mild acute stress situation, the intracellular signal transduction mediated by 5-HT was promptly inhibited as compared to the signal transduction mediated by NA or carbachol. This inhibition may be induced by an acute uncoupling of 5-HT 2 receptor-mediated intracellular signal transduction.
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