Abstract
Biomaterials having stimuli response are interesting in the biomedical field. This paper reports about swelling response and internal structural of biomineralized (CaCO3) polyvinylpyrrolidone (PVP) carboxymethylcellulose (CMC) hydrogel having various thicknesses (0.1–0.4 mm). Samples were tested in aqueous solution using temperature ranges from 10 to 40 °C; pH varies from 4 to 9, time 60 min. In addition, an experiment was conducted in the presence of simulated biological solutions (SBS): glucose (GS), physiological fluid (PS) and urea (US) at temperature 37 °C and pH 7.5 for 180 min. It is noticed that the maximum swelling ratio reached in 30–40 °C at pH 7 in aqueous solution. Among biological fluids, the swelling ratio shows: US > PS > GS at temperature 37 °C, pH 7.5, time 150 min. The equilibrium swelling ratio of the test sample in SBS and their non-reformative apparent structure confirm that biomineralized (CaCO3) PVP–CMC hydrogel can be acclaimed for medical application like bone tissue engineering.Graphical
Highlights
In the new era of biomedical field of tissue engineering and regenerative medicines, the utilization of materials generally comes in contact with any biological resources, in the form of either cells, tissues/organs, biomolecules, physiological fluids, etc., which desire the interdisciplinary scientific approach that merges the field of material science and technology, basic science and life science (Mano et al 2007)
This paper reports about swelling response and internal structural of biomineralized (CaCO3) polyvinylpyrrolidone (PVP) carboxymethylcellulose (CMC) hydrogel having various thicknesses (0.1–0.4 mm)
The overall results obtained through this study indicated that there exists a strong electrostatic interaction within the biomineralized (CaCO3) PVP–CMC hydrogel
Summary
In the new era of biomedical field of tissue engineering and regenerative medicines, the utilization of materials generally comes in contact with any biological resources, in the form of either cells, tissues/organs, biomolecules, physiological fluids, etc., which desire the interdisciplinary scientific approach that merges the field of material science and technology, basic science and life science (Mano et al 2007). Because of adventitious properties of PVP–CMC hydrogel like: porous internal morphology, quite a good moisture/solvent/solution absorption capacity, flexible in nature for the preparation of sample for testing in different shape, size and thickness, this bio-based hydrogel has been chosen to be used as a matrix for the preparation of calcite (CaCO3) incorporated hydrogel. This calcite-filled hydrogel termed as biomineralized (CaCO3) PVP–CMC hydrogel which has been prepared following the liquid diffusion method (Rauch et al 2012; Saha et al 2013a, b; Shah et al 2014, 2015a, b, c). Attenuated total reflectance ATR-FTIR was used with NICOLET 320 FTIR Spectrophotometer with ‘‘Omnic’’ software package
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