Abstract
Triiodthyronine (T3) is a hormone, which binds to a receptor that acts as transcription factor. In the context of sarcomeric proteins, T3 induces the switch from β-myosin heavy chain (MyHC) to α-MyHC and regulates transition from N2BA-titin to N2B-titin. T3 is also used to mature human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). Maturation of hPSC-CMs requires expression of cardiac (ventricular) isoforms of sarcomeric genes. We thus wanted to know what happens to the transcription activity of other sarcomeric genes, e.g.
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