Abstract
The toxicity of several sulphonamides for tissue cells has been tested by adding the compounds to tissue cultures of fibroblasts (guinea pig heart tissue in guinea pig serum). Supersaturated solutions of sulphadiazine or sulphapyrazine, in serum, have no influence on the growth of fibroblasts. Sulphathiazole, N1-benzoyl-sulphanilamide, or sulphanilamide in similar concentrations inhibit fibroblast growth. The above-mentioned five sulphonamides in concentrations up to 100 mgm. per 100 ml. have no apparent influence on fibroblast growth. In contrast, azochloramide in concentrations of 5 to 10 mgm. per 100 ml. inhibit growth.
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