Influence of sulfinpyrazone on infarct size, hemodynamics, and arrhythmia following coronary occlusion in the pig.

Abstract

We compared infarct size (nitroblue tetrazolium method), hemodynamic variables, and arrhythmias of a group of seven sulfinpyrazone-treated pigs (30 mg/kg/day for 7 days preoperatively, 30 mg/kg/i.v. 30 min before coronary ligation) with a control group of seven animals. Infarct size after ligation of the left anterior descending coronary artery was 20.3 +/- 1.1% in the sulfinpyrazone group and 20.3 +/- 0.5% in the control group. Heart rate, arterial blood pressure, cardiac output, and stroke volume were comparable in both groups before and for 60 min following ligation. There was no significant difference between the two groups in the number of premature ventricular contractions the PVC grade (Lown) or in the number of episodes of ventricular tachycardia or ventricular fibrillation during the 30-min observation period. We conclude that short-term administration of sulfinpyrazone has no effect on infarct size or arrhythmias in the acutely ischemic myocardium of the pig.