Abstract
It is known that various cell types can sense and respond to the mechanical properties of their microenvironment. Specifically, cells have been known to spread more when cultured on stiff substrates and are able to match their internal stiffness to that of the substrate [1,2]. Building on earlier models [3,4], we present a model to estimate the cell spread area when cells are cultured on substrates of variable stiffness. Our model crucially invokes the ability of some cell types to adapt their internal stiffness and thus shows why stiff and thin substrates encourage some cells to spread more easily and why these cells can match their internal stiffness to external stiffness more efficiently than others.Reference:
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