Abstract
This work assessed the influence of structural, textural and surface features of mesostructured silica and aluminosilicate carriers on aminoglycosides encapsulation and in vitro release. A series of pure and functionalized mesostructured silica, as well as aluminosilicates, which belong to MCM-41, MCM-48 and SBA-15 classes, and two aminoglycosides with related structure, amikacin and kanamycin as biologically-active molecules were employed in order to prepare drug delivery systems. No significant toxicity of studied mesoporous carriers on MEF cells after 72h of continuous exposure to 100μg/mL nanoparticles was noticed. The mesostructured supports and amikacin- and kanamycin-based hybrid samples were characterized by small- and wide-angle XRD, FT-IR spectroscopy, thermogravimetric analysis, and N2 sorption isotherms. The uptake values for all amikacin-based hybrids are higher than those for kanamycin counterparts. Moreover, the first antibiotic can be loaded on functionalized (with 3-aminopropyl or methyl groups) SBA-15-type materials, unlike the last drug. Amikacin loaded into the mesopores of AlSBA-15 and SBA-15 vehicles exhibited a slower delivery rate than from MCM-48 and functionalized SBA-15 materials. Different than amikacin-based hybrids, kanamycin loaded on aluminosilicates (AlMCM-41 and AlSBA-15) caused faster delivery, the highest value of drug cumulative release at 24h being obtained for AlMCM-41 support.
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