Abstract
Background and aim Odontogenic tumors are tumors that arise from the odontogenic epithelium and/or odontogenic ectomesenchyme. Ameloblastoma (AB) and keratocystic odontogenic tumor (KCOT) are common epithelial odontogenic tumors that have an aggressive and invasive character. Tumor microenvironment has an important role in tumor behavior and growth as it provides nutrients, oxygen through angiogenesis and myofibroblasts (MFs). This work was aimed to study the stromal architecture such as collagen organization, microvessel density, and MFs' number in ABs and KCOTs and determine the stromal architecture influence on their aggressiveness. Material and methods Forty-eight specimens were used as follow, 24 ABs, 20 KCOTs, two ameloblastic carcinomas, and two tissues of dental follicle (as a normal control). Specimens were examined by Masson's trichrome special stain as well as anti-CD34 and anti-human alpha smooth muscle actin antibodies for immunohistochemical staining. Results Statistical significant differences between ABs and KCOTs in microvessel density as well as MF number were obviously noticed. Conclusion Stromal architecture of epithelial odontogenic lesions might be regarded not only a structural support, but it may have a role in the pathogenesis of these lesions.
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