Abstract
Effects of prenatal stress (daily 1-h-long immobilization of pregnant females at the 15th–21st days of pregnancy) on the formation of sex-related dimorphism of the turnover of noradrenaline (NA) and dopamine (DA) in the preoptic area (POA) of the brain and mediobasal hypothalamus (MBH) were studied in 10-day-old rats. Sex-related differences of the turnover of a functional NA pool in the POA and DA pool in the MBH were demonstrated in intact control rats: a higher rate of the monoamine turnover was observed in males. Prenatal stress abolished these sex-related differences and, at the same time, induced such differences in the DA turnover in the POA. It is supposed that prenatal stress-evoked early modifications of sex-related dimorphism of the catecholamine turnover in the brain can result in the development of remote disturbances in the neuroendocrine control of reproduction and adaptation.
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