Abstract
Recent studies suggest that lecithin-rich diet can modify cholesterol homeostasis and hepatic lipoprotein metabolism. Considering the phytotherapeutic impact of lecithin, this work hypothesizes that lecithin administration in hypercholesterolemic patients may reduce cholesterol concentrations by increasing biliary secretion. Total cholesterol and LDL were evaluated after soy lecithin administration in hypercholesterolemic patients. One soy lecithin capsule (500 mg/RP-Sherer) was administrated daily. One-two months before the treatment beginning, blood samples were collected for total lipids and cholesterol fractions analysis. The results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia.
Highlights
IntroductionLipid metabolism studies include a vision for the lipoprotein structure, function, and a description of the lipid metabolism forms, indicating that the dyslipidemias are important risk factors in the context of cardiovascular disease and that appropriate intervention can have a significant impact on clinical treatment [1]
Lipid metabolism studies include a vision for the lipoprotein structure, function, and a description of the lipid metabolism forms, indicating that the dyslipidemias are important risk factors in the context of cardiovascular disease and that appropriate intervention can have a significant impact on clinical treatment [1].Atherosclerosis, the most serious cardiovascular disease, may affect individuals at an early age (20–29 years)
A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia
Summary
Lipid metabolism studies include a vision for the lipoprotein structure, function, and a description of the lipid metabolism forms, indicating that the dyslipidemias are important risk factors in the context of cardiovascular disease and that appropriate intervention can have a significant impact on clinical treatment [1]. Atherosclerosis, the most serious cardiovascular disease, may affect individuals at an early age (20–29 years). The relationship between hypercholesterolemia and coronary atherosclerosis disease has been demonstrated in many clinical trials [2, 3]. It has been suggested that antioxidant substances are capable of reversing endothelial dysfunction caused by hypercholesterolemia [11,12,13] and reduce the number of coronary events [14], their use in medical practice still needs more conclusive information
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