Abstract
The effects of some steroids of the testosterone and 19-nortestosterone groups on the phosphorylative oxidation of ketoglutarate by isolated rat liver mitochondria and on the O 2 uptake and aerobic glycolysis of hepatoma AH 130 ascites cells have been compared. The ratios between oxidation inhibiting activity and oxidative phosphorylation uncoupling efficiency of some of the steroids tested are widely different. Both inhibitors of oxidations and uncouplers of oxidative phosphorylations cause an increase of aerobic glycolysis in intact hepatoma ascites cells. Only the oxidation of DPN-dependent substrates is influenced by these compounds. The steroids inhibiting mitochondrial oxidations decrease the rate of external DPNH reoxidation by mitochondria pretreated with hypotonic solutions, some steroids which do not inhibit mitochondrial oxidations have the same effect in a lesser degree. 16α-Hydroxy-17α-methyltestosterone has the highest uncoupling activity that has been so far described for a steroid compound.
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