Abstract
AbstractThe reactions of 1‐chloro‐ and 1‐fluoro‐2,4‐dinitrobenzenes with aniline and 4‐methylaniline in dimethyl sulphoxide are not base catalysed. When the nucleophile is 2‐methylaniline, the reaction of the fluoro compound is base catalysed whereas that of the chloro compound is not. The reactions of 1‐bromo‐2‐fluoro‐ and 1‐bromo‐2‐chloro‐3,5‐dinitrobenzenes with both aniline and 2‐methylaniline are not base catalysed. These results indicate that, in certain cases, the incidence or absence of base catalysis in aromatic nucleophilic substitution (SNAr) reactions in dipolar aprotic solvents results from an interplay of steric and electronic factors as they affect the magnitude of the (k2 + k3 [B])/k−1 ratio.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
