Abstract
Effects of insecticides upon both target and non-target organisms often reflect interaction with cellular membranes (Matsumura and O'Brien, 1966). For instance, in the case of vertebrates, these effects include inhibition of plasma membrane ATPase (adenosine triphosphatase) (Davis et al. 1972), increased metabolic transformations by microsomal membranes (Remmer et al. 1967), and disruption of osmotic equilibrium (Janicki and Kinter 1971). Since mitochondrial energy coupling is localized in the inner mitochondrial membrane and since coupling is highly sensitive to assault on the integrity of that membrane, we have undertaken to examine the action of insecticides on processes associated with mitochondrial energy conservation. The present communication presents data indicating that low concentrations of several chemically-unrelated insecticides stimulate mouse mitochondrial ATPase in a manner similar to that of uncouplers of oxidative ATP synthesis.
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