Abstract
An interesting approach for the synthesis of xanthine skeletons by a copper-catalyzed reaction between N,N′-dialkylated 5-bromouracil derivatives and amidines are being reported. The coupling reaction was promoted by catalytic amount of Cu(OAc)2 in the presence of molecular O2. The 1,4-dioxane was found to be a better solvent for the reaction and the reaction was believed to go through a N-arylation and subsequent C-H activation/C-N bond formation process.
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