Abstract
The effect of sodium salicylate on the metabolism of 3T6 fibroblasts treated with the lathyrogen β-aminopropionitrile was studied. A 5mM concentration of the lathyrogen and/or 0.5mM sodium salicylate was used to study proliferation, collagen synthesis, and mucopolysaccharide synthesis as measured by 35SO4 incorporation. Sodium salicylate was able to reverse all lathyrogen-mediated changes to control or near control values. The diversity of these biosynthetic activities suggests that the influence of sodium salicylate on lathyrogen-treated cells is a result of a general metabolic effect rather than a specific one; the exact mechanism of action remains unknown.
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