Influence of single pass recanalization in acute ischemic stroke with large vessel occlusion in patients of Asian ethnicity

Abstract

Background and purposeA previous report revealed single pass recanalization was associated with better functional outcome for patients with acute ischemic stroke with large vessel occlusion in real-world settings. However, the effect of single pass recanalization in acute large vessel occlusion based on the largest registry in real-world settings in Asian population are not well scrutinized. Materials and methodsRESCUE-Japan Registry-2 was a physician-initiated prospective multicenter registry that enrolled consecutive patients with acute large vessel occlusion who were admitted within 24 h of onset. We compared patients who underwent endovascular therapy and achieved good recanalization in single or multiple device passes (single-pass group and multiple-passes group, respectively) in terms of the good outcome defined as modified Rankin Scale of 0–2 at 90 days after onset. We estimated the odds ratios, safety and mortality adjusting for confounders. ResultsAmong 2420 patients registered, 1281 patients treated with endovascular therapy. 829 patients were analyzed (557 patients in single-pass and 272 patients in multiple-passes group). Patient characteristics were almost similar between two groups. The good outcome was more observed of patients in the single groups (51.5% vs 39.3%). The adjusted odds ratio of single pass of good outcome was 1.92 (95% confidence interval, 1.37–2.69). The frequencies of symptomatic intracranial hemorrhage were similar between the two groups. ConclusionSingle pass recanalization was associated with good clinical outcome on real-world settings in Asian population.