Abstract
Introduction: In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for. The study undertaken was aimed at studying one of such systems consisting of a prosthesis coated with silver ions.
 Materials and methods: The material for the study was standard endoprostheses produced by Lintex LLC (St.-Petersburg) for plastic repair of the anterior abdominal wall: Esfil and Uniflex, as well as Plasmofilter produced by Plasmofilter JSC (St.-Petersburg) and a pharmacotherapeutic system containing silver ions (FCS) applied to the experimental samples of endoprostheses – Esfil Ag and Unifleks Ag (patent RU 2473369C1), which were implanted into male Wistar rats. The results were evaluated using morphological, morphometric, immunohistochemical, ionometric, microbiological and statistical methods.
 Results and discussion: As a result, it was found that the use of the FCS leads to a more rapid change in inflammation phases. The formation of a mature connective tissue capsule with a thickness of 4.5±0.01 mm was observed by Day 30. The study of the cellular component of the periprosthetic tissue revealed the prevalence of resident cells. The proliferative activity of fibroblastic cells when using FCS over 14 days was statistically significantly (p≤0.05) 3.5-time higher. Microbiological studies confirmed the antibacterial properties of FCS in vivo and in vitro.
 Conclusion: The use of FCS contributes to the acceleration of reparative processes, earlier resolution of inflammation and stimulation of collagenesis both under sterile conditions and under microbial conditions.
Highlights
In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for
In sterile conditions by Day 14, when using FCS based on Uniflex Ag, the area reduced 2.5 times, and using FCS based on Esfil Ag – 2.4 times
That is why the development of new pharmacotherapeutic systems, made as mesh polypropylene or polypropylene-polyvinylidene fluoride endoprostheses with silver ions on their surface, has considerable advantages over all existing antimicrobial medications, since silver compounds have a wide range of antibacterial activity and have no disadvantages in terms of the problem of resistance of pathogenic microorganisms to them
Summary
In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for. The fact that there was no cytotoxic effect towards the cellular component of tissues surrounding a FCS with silver ions for prosthetics of the anterior abdominal wall was confirmed by an increase in the proliferative activity index, using the cell proliferation marker Ki-67.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
