Abstract
An expression having a basic cubic form was derived to describe the in vitro release of drugs from slow-release tablets formulated with a homogeneous insoluble matrix. While the rate of drug release varies with tablet shape, rate constants that are independent of shape are included in the expression. By comparison with previously published work, it was shown that the rate constants may be described in terms of the physicochemical properties of the tablet constituents and the degree of compression. Therefore, it should be possible to evaluate the rate constants for model formulations and then, using the pertinent release expression, to predict the rate of drug release from tablets having identical compositions but varying widely in shape and size.
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