Abstract
It has been shown1 that during pregnancy there is a great increase in the number of mononuclear phagocytic cells in the wall of the rabbit's uterus. This report is of an attempt to determine the extent to which this phenomenon might be attributed to hormonal factors, and is based on results obtained with over 70 female rabbits. In all instances the macrophages were demonstrated by intravital staining. Each animal was given intravenously from 20 to 25 cc. per kilo body weight, of a 1% aqueous solution of Trypan Blue, over a period of 3 days. They were sacrificed on the fourth day, and paraffin sections of the uteri were made using alum carmine as the counter stain.It was found that (1) in the uterus of the normal unmated rabbit small numbers of faintly-staining macrophages are generally present, while they are completely absent in the atrophic uterus of spayed animals, and (2) the induction of progestational proliferation in the rabbit's uterus by the intravenous injection of urine from pregnant women or o...
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