Abstract
SummaryThe sera from BALB/c mice were found to contain uniformly high levels of inhibitors which acted in vitro by blocking the effect of colony stimulating factor in stimulating colony formation by mouse bone marrow cells. These inhibitors could be inactivated by ether extraction and heating and were removable by dialysis. The inhibitors exhibited partial species specificity, were not toxic for colony‐forming cells but led to the preture transformation of granulocytic cells to macrophages in developing colonies. Bone marrow cells from BALB/c mice contained lower numbers of in vitro colony‐forming cells and produced a lower percentage of granulocytic colonies when stimulated in culture than did cells from C57BL mice (a strain with low serum inhibitor levels). Mice with myelomonocytic leukaemia developed low serum inhibitor levels in the advanced stages of the disease.
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