Abstract
Current treatment strategies for peptic ulcers caused by Helicobacter pylori includes quadruple therapy with limited effectiveness. The work focused on surface modulation of metallic nanopopcorns for adsorption of bismuth subnitrate to detect and kill H. pylori by the influence of Surface Enhanced Raman Spectroscopic (SERS), a surface-sensitive method is used for theranostics application. Nanopopcorns prepared by Terkevich method and characterized for morphology, adsorption, spectroscopic and in-vitro drug release studies. Adsorption efficiency of the nanopopcorns for bismuth subnitrate was 79.9%. In-vitro release studies showed initial burst release, followed by controlled release for 24 h. SERS analysed the nanopopcorn's activity on the bacteria and their subsequent cell death pattern. Novel drug delivery system with large surface area offers effective strategies for diagnosis and treatment in various diseases.
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