Year-end Sale % OFF 
Abstract
Neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) belong to the major Aβ-degrading enzymes. We currently demonstrate that apigenin, luteolin, and curcumin are able to enhance the activity of NEP and ACE. In this research, we examined the influence of these substances on the amount of endogenously produced and secreted Aβ of neuroblastoma cells. We found that treatment of the cells for 72 h with apigenin, luteolin, and curcumin decreases the endogenous Aβ 1-42 level of SK-N-SH cells significantly, which indicates that the upregulation of both NEP and ACE activity leads to a decrease of Aβ in the medium. Furthermore, we showed that all of these substances are able to increase the intracellular cAMP level, which verifies our previous supposition that the enhancement of cellular NEP activity is correlated with an increase of cAMP level.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
