Abstract
Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space. AimTo evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation. Materials and MethodsThis was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out. ResultsThe side on which glue was applied had an average of 27.8% against 20.4% of the side without glue. ConclusionThe collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue.
Highlights
The collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue
The presence of a fibrin sealant stimulates fibrogenesis in this tissue
Fibrin sealants or fibrin glue are products made from human plasma proteins; they mimic the final pathway of the coagulation cascade
Summary
Fibrin sealants or fibrin glue are products made from human plasma proteins; they mimic the final pathway of the coagulation cascade. In these products, fibrinogen is cleaved by proteolysis and converted into fibrin polymers by the effect of thrombin. Clark[9] has stated that using fibrin sealants to avoid adhesions or fibrosis is contradictory because fibrinogen stimulates production of collagen. The majority of experimental clinical studies on the use of fibrin sealants in several tissues have yielded good results; in these studies, fibrin glue reduces fibrosis and tissue adhesion in different surgical fields compared to controls[10]
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