Abstract
The effect of successive inocula of tumour cells given to rats at intervals of 1 to 10 days was examined. If W256 cells were injected on both occasions, the second inoculum failed to grow if given into the footpad as early as 1 day, or intravenously as soon as 4 days, after the first administration. However, although a second inoculum failed to grow, it produced significant augmentation of the growth of the primary implant if given during its latent or growth phases. If the second inoculum contained cells from a fibrosarcoma unrelated to W256, its growth was effectively curtailed if the initial inoculum had preceded it by 24 h or more. However, secondary inocula of fibrosarcoma cells did not augment the growth of the primary W256 tumour.
Highlights
Summary.-The effect of successive inocula of tumour cells given to rats at intervals of 1 to 10 days was examined
The mutual influence exerted on the growth of each other by two inocula of tumour cells which had been administered to the same host has been examined
It was found that following the injection of Walker 256 carcinoma (W256) cells into one footpad, the growth of a second, similar inoculum in the contralateral footpad was prevented, even if this was administered within 24 h of the first
Summary
Summary.-The effect of successive inocula of tumour cells given to rats at intervals of 1 to 10 days was examined. A second inoculum failed to grow, it produced significant augmentation of the growth of the primary implant if given during its latent or growth phases. Whilst the influence of a primary tumour on the establishment and growth of spontaneous or artificially induced secondary tumours has been thoroughly documented, there have been few investigations of the influence of the second implant on the growth of the primary. This effect may be relevant to clinical observations in humans, where an apparent change in the growth pattern of the primary tumour could be due to the establishment of metastases. The influence of the second challenge on the growth of the first implant, and the extent of immunity of the host towards a second challenge, were examined following readministration of tumour cells at different sites during either the growth or regression phases of the first implant
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