Abstract
Three different models for the induction of gastric ulcers in rats (phenylbutazone, 200 mg/kg; swimming, 3 × 30 min, water temperature 26–27°C; immobilization, 30 hours) were used to investigate the influence of weather and season. In a systematic study experiments were carried out weekly over a period of one year with male (phenylbutazone, immobilization) and female (swimming) rats of the same age kept under controlled conditions. The highest incidence of gastric ulcers was found in the swimming test; the lowest in the immobilization test. Maximum and minimum gastric ulcer rates were observed for each test but at different times. There was no uniform seasonal pattern. With decreasing atmospheric pressure a higher incidence of gastric ulcers was found 24 hours before the phenylbutazone and immobilization tests. Low atmospheric pressure and high relative humidity during the phenylbutazone and swimming tests also caused a higher incidence of gastric lesions (P<0.05). No correlation was found between the other meteorological conditions and the incidence of gastric ulcer.
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